1-Acetylpiperazine → 5-{6-[(4-acetylpiperazin-1-yl)methyl]-1H-imidazo[4,5-c]pyridin-1-yl}-3-{(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy}thiophene-2-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	1-Acetylpiperazine	HCID 83795	—
Reactant	[1-(5-carbamoyl-4-{(1R)-1-[2-(trifluoro-methyl)phenyl]ethoxy}-2-thienyl)-1H-imidazo[4,5-c]pyridin-6-yl]methyl methanesulfonate	HCID 86647102	—
Solvent	Dichloromethane	HCID 6344	—
Product	5-{6-[(4-acetylpiperazin-1-yl)methyl]-1H-imidazo[4,5-c]pyridin-1-yl}-3-{(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy}thiophene-2-carboxamide	HCID 68766613	—

Reaction Steps

In a similar manner as described for example 58, 108 mg of [1-(5-carbamoyl-4-{(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy}-2-thienyl)-1H-imidazo[4,5-c]pyridin-6-yl]methyl methanesulfonate and 128.2 mg of 1-acetylpiperazine in 2.5 ml dichloromethane give the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08273890B2
Source dataset	uspto-grants-2012_09
ORD ID	ord-71820c692c0e4e2db3598cbe8d7183e5
Source note	uspto-grants-2012_09