HRID2391642

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2737134

1-(1-Phenylethyl)piperazine

C12H18N2

结构：C[C@@H](Oc1cc(-n2cnc3cnc(COS(C)(=O)=O)cc32)sc1C(N)=O)c1ccccc1C(F)(F)F

HCID86647102

未命名化合物

PRODUCTS

生成物

结构：CC(c1ccccc1)N1CCN(Cc2cc3c(cn2)ncn3-c2cc(O[C@H](C)c3ccccc3C(F)(F)F)c(C(N)=O)s2)CC1

HCID68769183

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

In a similar manner as described for example 58, 108 mg of [1-(5-carbamoyl-4-{(1R)-1-[2-(trifluoromethyl)phenyl]ethoxy}-2-thienyl)-1H-imidazo[4,5-c]pyridin-6-yl]methyl methanesulfonate and 190.3 mg of 1-(1-phenylethyl)piperazine in 2.5 ml dichloromethane give the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1469b68a4726400abac43b553a490044
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08273890B2
来源说明: uspto-grants-2012_09

反应 SMILES

CS(O[CH2:6][C:7]1[N:12]=[CH:11][C:10]2[N:13]=[CH:14][N:15]([C:16]3[S:17][C:18]([C:34](=[O:36])[NH2:35])=[C:19]([O:21][C@@H:22]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=4[C:30]([F:33])([F:32])[F:31])[CH3:23])[CH:20]=3)[C:9]=2[CH:8]=1)(=O)=O.[C:37]1([CH:43]([N:45]2[CH2:50][CH2:49][NH:48][CH2:47][CH2:46]2)[CH3:44])[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1>ClCCl>[C:37]1([CH:43]([N:45]2[CH2:46][CH2:47][N:48]([CH2:6][C:7]3[N:12]=[CH:11][C:10]4[N:13]=[CH:14][N:15]([C:16]5[S:17][C:18]([C:34]([NH2:35])=[O:36])=[C:19]([O:21][C@@H:22]([C:24]6[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=6[C:30]([F:31])([F:32])[F:33])[CH3:23])[CH:20]=5)[C:9]=4[CH:8]=3)[CH2:49][CH2:50]2)[CH3:44])[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=1