HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 86647113, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 3-[(1R)-1-(2-chlorophenyl)ethoxy]-5-[6-(hydroxymethyl)-1H-imidazo[4,5-c]pyridin-1-yl]thiophene-2-carboxamide | HCID 68769268 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86647113 | HCID 86647113 | — |
Reaction Steps
In a similar manner as described for example 49 (step 1), 428 mg of 3-[(1R)-1-(2-chlorophenyl)ethoxy]-5-[6-(hydroxymethyl)-1H-imidazo[4,5-c]pyridin-1-yl]thiophene-2-carboxamide, 229 mg of methanesulfonyl chloride, and 202 mg of triethylamine in 10 ml dichloromethane give (1-{5-carbamoyl-4-[(1R)-1-(2-chlorophenyl)ethoxy]-2-thienyl}-1H-imidazo[4,5-c]pyridin-6-yl)methyl methanesulfonate as crude material that is used for step 2 without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273890B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-8c9649be554f4cfc95247e0f58e9f612 |
| Source note | uspto-grants-2012_09 |