HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 86647112, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | (1-[2-(difluoromethoxy)phenyl]ethoxy}-5-[6-(hydroxymethyl)-1H-imidazo[4,5-c]pyridin-1-yl]thiophene-2-carboxamide | HCID 86647107 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86647112 | HCID 86647112 | — |
Reaction Steps
In a similar manner as described for example 49 (step 1), 511 mg of 3-{(1-[2-(difluoromethoxy)phenyl]ethoxy}-5-[6-(hydroxymethyl)-1H-imidazo[4,5-c]pyridin-1-yl]thiophene-2-carboxamide, 252 mg of methanesulfonyl chloride, and 223 mg of triethylamine in 11 ml dichloromethane give [1-(5-carbamoyl-4-{1-[2-(difluoromethoxy)phenyl]ethoxy}-2-thienyl)-1H-imidazo[4,5-c]pyridin-6-yl]methyl methanesulfonate as crude material that is used for step 2 without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273890B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-a00785824d7649958cb370b1b8f923a6 |
| Source note | uspto-grants-2012_09 |