HRID2391668

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID222

Ammonia gas

H3N

结构：COC(=O)c1sc(-n2cnc3cnc(CO[Si](C)(C)C(C)(C)C)cc32)cc1O[C@@H](CO[Si](C)(C)C(C)(C)C)c1ccccc1Cl

HCID68768690

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)[Si](C)(C)OCc1cc2c(cn1)ncn2-c1cc(O[C@@H](CO[Si](C)(C)C(C)(C)C)c2ccccc2Cl)c(C(N)=O)s1

HCID68766118

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

In a similar manner as described for example A5, 500 mg of methyl 3-[(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-(2-chlorophenyl)ethoxy]-5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1H-imidazo[4,5-c]pyridin-1-yl]thiophene-2-carboxylate and 40 ml of a saturated solution of ammonia in methanol yield the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6f9ef4ccd08a48e1b371445dddd72f10
来源数据集: uspto-grants-2012_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08273890B2
来源说明: uspto-grants-2012_09

反应 SMILES

[Si:1]([O:8][CH2:9][C@@H:10]([C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=1[Cl:45])[O:11][C:12]1[CH:16]=[C:15]([N:17]2[C:25]3[CH:24]=[C:23]([CH2:26][O:27][Si:28]([C:31]([CH3:34])([CH3:33])[CH3:32])([CH3:30])[CH3:29])[N:22]=[CH:21][C:20]=3[N:19]=[CH:18]2)[S:14][C:13]=1[C:35]([O:37]C)=O)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[NH3:46]>CO>[Si:1]([O:8][CH2:9][C@@H:10]([C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=1[Cl:45])[O:11][C:12]1[CH:16]=[C:15]([N:17]2[C:25]3[CH:24]=[C:23]([CH2:26][O:27][Si:28]([C:31]([CH3:34])([CH3:33])[CH3:32])([CH3:30])[CH3:29])[N:22]=[CH:21][C:20]=3[N:19]=[CH:18]2)[S:14][C:13]=1[C:35]([NH2:46])=[O:37])([C:4]([CH3:7])([CH3:5])[CH3:6])([CH3:2])[CH3:3]