Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2391671Generated: October 29, 2026

Ammonia → 5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1H-imidazo[4,5-c]pyridin-1-yl]-3-{-1-[2-(difluoromethoxy)phenyl]ethoxy}thiophene-2-carboxamide

https://huagongshe.com/reaction/2391671

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAmmoniaHCID 222—
ReactantHCID 68765391HCID 68765391—
SolventMethanolHCID 887—
Product5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1H-imidazo[4,5-c]pyridin-1-yl]-3-{-1-[2-(difluoromethoxy)phenyl]ethoxy}thiophene-2-carboxamideHCID 68767265—

Reaction Steps

In a similar manner as described for example A5, 2.78 g of methyl 5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1H-imidazo[4,5-c]pyridin-1-yl]-3-{-1-[2-(difluoromethoxy)phenyl]ethoxy}thiophene-2-carboxylate and 115 ml of a saturated solution of ammonia in methanol yield the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08273890B2
Source datasetuspto-grants-2012_09
ORD IDord-8c82ba1f4ebd41b9a13a299baa955515
Source noteuspto-grants-2012_09