Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2391696Generated: October 30, 2026

Potassium Carbonate → methyl 3-{[4-fluoro-2-(trifluoromethyl)benzyl]oxy}-5-(1H-imidazo[4,5-c]pyridin-1-yl)thiophene-2-carboxylate

https://huagongshe.com/reaction/2391696

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium CarbonateHCID 11430—
Reactant4-Fluoro-2-(trifluoromethyl)benzyl bromideHCID 2737576—
Reactantmethyl 3-hydroxy-5-(1H-imidazo[4,5-c]pyridin-1-yl)thiophene-2-carboxylateHCID 68766294—
SolventDimethylformamideHCID 6228—
Productmethyl 3-{[4-fluoro-2-(trifluoromethyl)benzyl]oxy}-5-(1H-imidazo[4,5-c]pyridin-1-yl)thiophene-2-carboxylateHCID 68768151—

Reaction Steps

In a similar manner as described for example B14, 110.5 mg of 4-fluoro-2-(trifluoromethyl)benzyl bromide, 100 mg of methyl 3-hydroxy-5-(1H-imidazo[4,5-c]pyridin-1-yl)thiophene-2-carboxylate, 59.7 mg of potassium carbonate in 3 ml anhydrous DMF yield the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08273890B2
Source datasetuspto-grants-2012_09
ORD IDord-0d14923576004aa882360c5e5ffddadd
Source noteuspto-grants-2012_09