HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → N-benzyl-5-bromohexahydro-4-azepinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 1-Benzyl-hexahydro-4H-azepin-4-one | HCID 1514350 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | N-benzyl-5-bromohexahydro-4-azepinone | HCID 20803026 | — |
Reaction Steps
33% hydrobromic acid in conc. acetic acid and 1.97 g bromine was added to 5 g 1-benzyl-azepane-4-one in 15 mL conc. acetic acid. The reaction was stirred 2 h at RT and completely concentrated under reduced pressure. The residue was diluted with ethyl acetate and refluxed for 1 h and crystallized with ethyl acetate to give 4 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642774B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-ad912c6a02b543b3b5f7f29869c07493 |
| Source note | uspto-grants-2014_02 |