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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2391701Generated: October 29, 2026

Potassium Carbonate → methyl 3-[(2-fluorobenzyl)oxy]-5-(1H-imidazo[4,5-c]pyridin-1-yl)thiophene-2-carboxylate

https://huagongshe.com/reaction/2391701

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium CarbonateHCID 11430—
Reactantalpha-Bromo-o-fluorotolueneHCID 67968—
Reactantmethyl 3-hydroxy-5-(1H-imidazo[4,5-c]pyridin-1-yl)thiophene-2-carboxylateHCID 68766294—
SolventDimethylformamideHCID 6228—
Productmethyl 3-[(2-fluorobenzyl)oxy]-5-(1H-imidazo[4,5-c]pyridin-1-yl)thiophene-2-carboxylateHCID 68765200—

Reaction Steps

In a similar manner as described for example B11, 172 mg of 1-(bromomethyl)-2-fluorobenzene, 200 mg of methyl 3-hydroxy-5-(1H-imidazo[4,5-c]pyridin-1-yl)thiophene-2-carboxylate, 121 mg of potassium carbonate in 5 ml anhydrous DMF yield the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08273890B2
Source datasetuspto-grants-2012_09
ORD IDord-c10141ea8b804359ad7eca8a49a5bbd0
Source noteuspto-grants-2012_09