HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 239171Generated: October 29, 2026
Urea → 5,6,7,8-Tetrahydro-4H-oxazolo[4,5-d]azepin-2-ylamine
https://huagongshe.com/reaction/239171
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Urea | HCID 1176 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 5-Bromoazepan-4-one hydrobromide | HCID 22620766 | — |
| Product | 5,6,7,8-Tetrahydro-4H-oxazolo[4,5-d]azepin-2-ylamine | HCID 84649760 | 23.8% |
Reaction Steps
6.6 g urea was added to 6 g 5-bromo-azepan-4-one hydrobromide and heated 24 h at 70° C. 4 M aqueous sodium hydroxide was added and the mixture was extracted with chloroform and ethyl acetate. The combined organic layers were evaporated to give 800 mg of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08642774B2 |
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| Source dataset | uspto-grants-2014_02 |
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| ORD ID | ord-c93483b6efbc4b8aaedb56e7bd43aade |
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| Source note | uspto-grants-2014_02 |
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