HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → HCID 68767229, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Di-tert-butyl azodicarboxylate | HCID 97268 | — |
| Reactant | (1S)-1-(2-Fluorophenyl)ethan-1-ol | HCID 7023576 | — |
| Reactant | methyl 5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1H-imidazo[4,5-c]pyridin-1-yl]-3-hydroxythiophene-2-carboxylate | HCID 68766707 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 68767229 | HCID 68767229 | — |
Reaction Steps
In a similar manner as described for example B31, 2.31 g of methyl 5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1H-imidazo[4,5-c]pyridin-1-yl]-3-hydroxythiophene-2-carboxylate, 0.92 g of (1S)-1-(2-fluorophenyl)ethanol, 3.67 g of triphenylphosphine (polymer bound, ˜3 mmol/g) and 2.53 g of di-tert-butyl azodicarboxylate in 65 ml anhydrous dichloromethane yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273890B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-9477e46b08b94cb1b0bb1db5ee5dc2f0 |
| Source note | uspto-grants-2012_09 |