HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → methyl 5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1H-imidazo[4,5-c]pyridin-1-yl]-3-{[1-(2-chlorophenyl)propyl]oxy}thiophene-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Di-tert-butyl azodicarboxylate | HCID 97268 | — |
| Reactant | 1-(2-Chlorophenyl)-1-propanol | HCID 4350706 | — |
| Reactant | methyl 5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1H-imidazo[4,5-c]pyridin-1-yl]-3-hydroxythiophene-2-carboxylate | HCID 68766707 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | methyl 5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1H-imidazo[4,5-c]pyridin-1-yl]-3-{[1-(2-chlorophenyl)propyl]oxy}thiophene-2-carboxylate | HCID 68767277 | — |
Reaction Steps
In a similar manner as described for example B31, 3.0 g of methyl 5-[6-({[tert-butyl(dimethyl)silyl]oxy}methyl)-1H-imidazo[4,5-c]pyridin-1-yl]-3-hydroxythiophene-2-carboxylate, 1.83 g of 1-(2-chlorophenyl)propan-1-ol, 4.76 g of triphenylphosphine (polymer bound, ˜3 mmol/g) and 3.29 g of di-tert-butyl azodicarboxylate in 85 ml anhydrous dichloromethane yield the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273890B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-5a553aed50d746a49e5b41f5be838542 |
| Source note | uspto-grants-2012_09 |