Formic Acid → HCID 21683295, compound

HRID 2391733Notes

Reaction equation

HRID 2391733 reaction equation
Cl.Cl.[CH3:3][O:4][C:5]1[N:10]=[C:9]([NH2:11])[C:8]([NH2:12])=[CH:7][CH:6]=1.[CH:13](O)=O>>[CH3:3][O:4][C:5]1[N:10]=[C:9]2[N:11]=[CH:13][NH:12][C:8]2=[CH:7][CH:6]=1

Participants

3

Reactant 2

HCID 284Formic AcidHCID 30239196-Methoxy-2,3-pyridinediamine HCl

Product 1

HCID 21683295HCID 21683295, compound

Procedure

10.19 g of 6-methoxypyridine-2,3-diamine dihydrochloride were dissolved in 100 ml formic acid and stirred under reflux for 72 h. The formic acid was evaporated under vacuum and the residue was dried under vacuum at 95° C. to give crude 5-methoxy-1H-imidazo[4,5-b]pyridine (as hydrochloride and/or as formic acid salt and/or as free base) that was used for the following step without further purification.

Workup

  1. temperatureunder reflux for 72 h
  2. customThe formic acid was evaporated under vacuum
  3. customthe residue was dried under vacuum at 95° C.

Sources & evidence

ORD record
ord-861b197e53da4238a76a9264b8651928
Source dataset
uspto-grants-2012_09
Patent number
US08273890B2

Reaction notes

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