Ammonia → HCID 178501028, compound

Participants

Reaction Steps

Into a mixture of 188.25 g methyl (65)-4,5,6,7-tetrahydro-imidazo[4,5-c]pyridine-6-carboxylate dihydrochloride in 3 l dichloromethane at 10-15° C. is lead gaseous ammonia until saturation takes place (about one hour). 200 ml methanol are added and the mixture is filtered. The filter cake is washed with 2×100 ml DCM/MeOH (8/2 v/v). The filtrate is concentrated under reduced pressure and the resulting solid is dried under vacuum to give 128.4 g of the title product.

Provenance & Evidence