反应详情

温度

0 °C

To 150 ml of concentrated sulfuric acid were added at 0° C. 150 ml fuming nitric acid. 40.0 g of 2,6-dibromo-3-methoxypyridine (example E2) were added portionwise to this mixture at 0° C. The reaction mixture was stirred for 45 minutes at 0° C. and then heated to 65° C. for 2 h. The mixture was poured into 2 l of crushed ice and stored at 0° C. overnight. The resulting precipitate was filtered, washed with water and dried under vacuum to yield the title compound.

1. temperatureheated to 65° C. for 2 h
2. waitstored at 0° C. overnight
3. filtrationThe resulting precipitate was filtered
4. washwashed with water
5. customdried under vacuum