HCID 24851925, compound → HCID 68767239, compound

Participants

Reaction Steps

To a solution of 1.5 g of 4-acetyl-3-chlorobenzonitrile in 25 ml anhydrous THF is added 158 mg sodium boron hybrid at 0° C. The ice bath is removed and the reaction mixture is stirred for 18 h at room temperature. The reaction mixture is poured into 90 ml of 1N aqueous HCl solution. The aqueous layer is extracted with ethyl acetate (3×50 ml). The combined organic layers are washed with a saturated solution of sodium chloride (100 ml), dried over MgSO4 and evaporated to dryness under reduced pressure. The remaining residue is purified by flash chromatography (n-hexane/ethyl acetate, 6/4 (v/v)) to yield the title compound.

Provenance & Evidence