1-Ethyl-4-(4-nitrobenzyl)piperazine → 4-[(4-Ethylpiperazin-1-yl)methyl]aniline

HRID 2391771Notes

Reaction equation

HRID 2391771 reaction equation
[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([N+:16]([O-])=O)=[CH:12][CH:11]=2)[CH2:5][CH2:4]1)[CH3:2]>C(Cl)Cl.CO>[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=2)[CH2:5][CH2:4]1)[CH3:2]

Participants

3

Reactant 1

HCID 7925571-Ethyl-4-(4-nitrobenzyl)piperazine

Product 1

HCID 10849964-[(4-Ethylpiperazin-1-yl)methyl]aniline

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Step 11.1 but using 1-ethyl-4-(4-nitro-benzyl)-piperazine (Step 12.2): ESI-MS: 220.1 [M+H]+; TLC: Rf=0.08 (DCM/MeOH+1% NH3aq, 9:1).

Sources & evidence

ORD record
ord-ae7b021b42da4b1f8cc0f56542a6cc69
Source dataset
uspto-grants-2012_09
Patent number
US08273882B2

Reaction notes

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