反应详情

11 g Dess Martin Periodane was added to 6.2 g 4-acetylamino-5-hydroxy-azepane-1-carboxylic acid benzyl ester in 100 mL dichloromethane and stirred for 1 h at RT. The mixture was diluted with dichloromethane and washed with 2 mol/L sodium hydroxide solution. The organic layer was washed with brine, dried and concentrated. The residue was purified by chromatographie on silica gel (EtOAc) to yield 5.5 g of the desired product. (M+H)+: 305

1. washwashed with 2 mol/L sodium hydroxide solution
2. washThe organic layer was washed with brine
3. customdried
4. concentrationconcentrated
5. customThe residue was purified by chromatographie on silica gel (EtOAc)