HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N'-(4-Fluoro-3-methyl-benzoyl)-hydrazinecarboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | tert-Butyl carbazate | HCID 70091 | — |
| Reactant | 4-Fluoro-3-methylbenzoyl chloride | HCID 2774589 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N'-(4-Fluoro-3-methyl-benzoyl)-hydrazinecarboxylic acid tert-butyl ester | HCID 86686514 | 80.1% |
Reaction Steps
11.2 g 4-fluoro-3-methyl-benzoyl chloride was added to 6.1 g triethylamine and 8 g hydrazinecarboxylic acid tert-butyl ester in 150 mL dichlormethane. The reaction was stirred for 1 h at RT and extracted with water. The organic layer was evaporated and the residue was crystallized from diisopropylether to yield 13 g of the desired product. Rt: 1.22 min (method B) (M+H)+: 269
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642774B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-d6ff8d03fa8342e3a93c550e0d21d3d1 |
| Source note | uspto-grants-2014_02 |