HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 178480842, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | MeOH tetrahydrofuran | HCID 21899815 | — |
| Reactant | 8-Isoquinolin-4-yl-quinoxaline-5-carboxylic acid [3-(4-ethyl-piperazin-1-yl)phenyl]-amide | HCID 44515669 | — |
| Reactant | HCID 178480844 | HCID 178480844 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 178480842 | HCID 178480842 | — |
Reaction Steps
The title compound was prepared in analogy to the procedures described in Example 14 but using 1-methyl-4-(2-nitro-1H-imidazol-4-ylmethyl)-piperazine (Step 20.1) instead of 2-nitroimidazole in Step 14.3, Raney nickel and MeOH/THF (1:1) instead of palladium on carbon and MeOH in Step 14.2, and 8-isoquinolin-4-yl-quinoxaline-5-carboxylic acid (Example 52) in Step 14.1. Title compound: ESI-MS: 479.0 [M+H]+; TLC: Rf=0.16 (DCM/MeOH, 9:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273882B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-7ac44bf19c404be7a533fbf1640bdae4 |
| Source note | uspto-grants-2012_09 |