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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2391815Generated: October 27, 2026

6-(4-Methylpiperazin-1-yl)pyridin-3-amine → 8-(2,6-Dimethyl-phenyl)-quinoxaline-5-carboxylic acid [6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-amide

https://huagongshe.com/reaction/2391815

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-(4-Methylpiperazin-1-yl)pyridin-3-amineHCID 2763390—
Reactant8-(2,6-Dimethyl-phenyl)quinoxaline-5-carboxylic acidHCID 66914574—
Product8-(2,6-Dimethyl-phenyl)-quinoxaline-5-carboxylic acid [6-(4-methyl-piperazin-1-yl)-pyridin-3-yl]-amideHCID 44516609—

Reaction Steps

The title compound was prepared in analogy to the procedure described in Step 14.1 but stirring the reaction mixture for 20 h at rt, using 6-(4-methylpiperazin-1-yl)-pyridin-3-ylamine (prepared as described in Example 33 but using N-methyl-piperazine in Step 33.2) and 8-(2,6-dimethyl-phenyl)-quinoxaline-5-carboxylic acid (Example 71). Title compound: ESI-MS: 453.1 [M+H]+; tR=3.55 min (System 1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08273882B2
Source datasetuspto-grants-2012_09
ORD IDord-d32c422715f64ddb9ff54d86617141be
Source noteuspto-grants-2012_09