Sulfuryl chloride → 8-(2-Chloro-5-methoxy-3,6-dimethyl-phenyl)-quinoxaline-5-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

Sulfuryl chloride (29 μL, 0.37 mmol) in CH3CN (1 mL) was added dropwise to a cold (−5° C.) suspension of 8-(3-methoxy-2,5-dimethyl-phenyl)-quinoxaline-5-carboxylic acid (Step 97.1) (113 mg, 0.37 mmol) in CH3CN (4 mL). The reaction mixture was stirred for 10 min at −5° C., quenched by addition of H2O (1 mL) and filtered to afford 42 mg of the title compound as a yellow solid. Title compound: ESI-MS: 343.0 [M+H]+; tR=4.90 min (System 1).

Provenance & Evidence