HCID 66914619, compound → HCID 59292910, compound

HRID 2391885Notes

Reaction equation

HRID 2391885 reaction equation
C([O:3][C:4]([C:6]1[C:7]2[N:8]=[CH:9][CH:10]=[N:11][C:12]=2[C:13]([C:16]2[C:21]([F:22])=[C:20]([O:23][CH3:24])[CH:19]=[C:18]([O:25][CH3:26])[C:17]=2[F:27])=[CH:14][CH:15]=1)=O)C.[CH3:28][N:29]([CH3:38])[CH2:30][CH2:31][N:32]1[CH:36]=[CH:35][C:34]([NH2:37])=[CH:33]1>C(Cl)Cl.CO>[CH3:28][N:29]([CH3:38])[CH2:30][CH2:31][N:32]1[CH:36]=[CH:35][C:34]([NH:37][C:4]([C:6]2[C:7]3[N:8]=[CH:9][CH:10]=[N:11][C:12]=3[C:13]([C:16]3[C:17]([F:27])=[C:18]([O:25][CH3:26])[CH:19]=[C:20]([O:23][CH3:24])[C:21]=3[F:22])=[CH:14][CH:15]=2)=[O:3])=[CH:33]1

Participants

4

Reactant 2

HCID 66914619HCID 66914619, compoundHCID 866411458-(2,6-Difluoro-3,5-dimethoxyphenyl)quinoxaline-5-carboxylic acid ethyl ester

Product 1

HCID 59292910HCID 59292910, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Step 14.1 but using 8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid ethyl ester (Step 124.1), 1-(2-dimethylamino-ethyl)-1H-pyrrol-3-ylamine (Step 121.1) and stirring the reaction mixture for 14 h at rt. Title compound: ESI-MS: 482.1 [M+H]+; tR=3.66 min (System 1); TLC: Rf=0.21 (DCM/MeOH, 9:1).

Workup

  1. customThe title compound was prepared in analogy to the procedure

Sources & evidence

ORD record
ord-29692589a52c4a5390b556be61a86898
Source dataset
uspto-grants-2012_09
Patent number
US08273882B2

Reaction notes

Loading…