HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-(2-(3,5-bis-(4-Fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl)-1-pyridin-2-yl-piperazin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-(Pyridin-2-yl)piperazin-2-one dihydrochloride | HCID 56777099 | — |
| Reactant | (3,5-bis-(4-Fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl chloride | HCID 86686520 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(2-(3,5-bis-(4-Fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl)-1-pyridin-2-yl-piperazin-2-one | HCID 71586500 | 30.6% |
Reaction Steps
160 mg 1-pyridin-2-yl-piperazin-2-one dihydrochloride was added to 216 mg (3,5-bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl chloride and 300 μL triethylamine in 10 mL dichlormethane. The reaction was stirred for 1 day at RT, the solvent was evaporated and the residue was purified by HPLC to yield 93 mg of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642774B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-501f0628135e4bc58d060a7e62a8ea8c |
| Source note | uspto-grants-2014_02 |