HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2391911Generated: October 31, 2026
5-(2,6-Dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid → 5-(2,6-Dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid (3H-imidazol-4-yl)-amide
https://huagongshe.com/reaction/2391911
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 5-(2,6-Dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid | HCID 59292911 | — |
| Reactant | HCID 178526856 | HCID 178526856 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 5-(2,6-Dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid (3H-imidazol-4-yl)-amide | HCID 59292948 | — |
Reaction Steps
The title compound was prepared in analogy to the procedures described in Example 14 but using 5-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid (Step 159.1), stirring the reaction mixture for 3 h at 70° C., and using 4-nitro-imidazole instead of 2-nitroimidazole in Step 14.3. The title compound: ESI-MS: 442.9 [M+H]+; tR=3.93 min (System 1); TLC: Rf=0.17 (DCM/MeOH/NH3aq, 94:5:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08273882B2 |
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| Source dataset | uspto-grants-2012_09 |
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| ORD ID | ord-485b88012ffb4f008b3299c3195f257e |
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| Source note | uspto-grants-2012_09 |
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