HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinamine → 5-(2,6-Dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid [5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinamine | HCID 45489910 | — |
| Reactant | 5-(2,6-Dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid | HCID 59292911 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 5-(2,6-Dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid [5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-yl]-amide | HCID 59292857 | — |
Reaction Steps
The title compound was prepared in analogy to the procedure described in Step 14.1 but using 5-(2,6-dichloro-3,5-dimethoxy-phenyl)-quinoline-8-carboxylic acid (Step 159.1), 5-(4-ethyl-piperazin-1-ylmethyl)-pyridin-2-ylamine (Step 26.1; purified by silica gel column chromatography), and stirring the reaction mixture for 20 h at rt. Title compound: ESI-MS: 580.1 [M+H]+; tR=3.80 min (System 1); TLC: Rf=0.27 (DCM/MeOH/NH3aq, 94:5:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08273882B2 |
| Source dataset | uspto-grants-2012_09 |
| ORD ID | ord-d881f2ff6aac41a3b6f270484d2ccdf8 |
| Source note | uspto-grants-2012_09 |