Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | MeOH tetrahydrofuran | HCID 21899815 | — |
| Reactant | 8-(2,6-Difluoro-3,5-dimethoxyphenyl)quinoxaline-5-carboxylic acid ethyl ester | HCID 86641145 | — |
| Reactant | HCID 178483302 | HCID 178483302 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 178493496 | HCID 178493496 | — |
Reaction Steps
The title compound was prepared in analogy to the procedures described in Example 14 but using 8-(2,6-difluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid ethyl ester (Step 124.1), stirring the reaction mixture for 7 h at 70° C., and using dimethyl-(2-nitro-1H-imidazol-4-ylmethyl)-amine (Step 22.1) instead of 2-nitroimidazole in Step 14.3, and Raney nickel and MeOH/THF (1:1) instead of palladium on carbon and MeOH in Step 14.2. The title compound: ESI-MS: 468.1 [M+H]+; tR=3.29 min (System 1); TLC: Rf=0.18 (DCM/MeOH/NH3aq, 91.5:7.5:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08273882B2 |
|---|
| Source dataset | uspto-grants-2012_09 |
|---|
| ORD ID | ord-60718f6764ba42f9847b47a4424fb932 |
|---|
| Source note | uspto-grants-2012_09 |
|---|
