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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2391963Generated: October 28, 2026

Hydrochloric Acid → HCID 57826814, compound

https://huagongshe.com/reaction/2391963

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantHCID 86633544HCID 86633544—
SolventDichloromethaneHCID 6344—
Solvent1,4-DioxaneHCID 31275—
ProductHCID 57826814HCID 5782681468.4%

Reaction Steps

To a solution of 1,1-dimethylethyl[(1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-(3-pyridinylmethyl)ethyl]carbamate (796.7 mg, 2.1 mmol) in DCM (10 mL) at RT was added 1M HCl in dioxane (10 mL). After 20 h, the solution was concentrated affording the title compound (404 mg, 68%) as the HCl salt: LCMS (ES) m/z 282 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08273782B2
Source datasetuspto-grants-2012_09
ORD IDord-e97b8a4bddd747e3a05f07e2941b742e
Source noteuspto-grants-2012_09