HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2392024Generated: October 30, 2026
N-bromobutanimide → methyl 4-(4-bromo-1-ethyl-1H-pyrazol-5-yl)-2-thiophenecarboxylate
https://huagongshe.com/reaction/2392024
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | methyl 4-(1-ethyl-1H-pyrazol-5-yl)-2-thiophenecarboxylate | HCID 67066137 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | methyl 4-(4-bromo-1-ethyl-1H-pyrazol-5-yl)-2-thiophenecarboxylate | HCID 57826836 | 78.5% |
Reaction Steps
To a solution of methyl 4-(1-ethyl-1H-pyrazol-5-yl)-2-thiophenecarboxylate (0.45 g, 1.9 mmol) [see example 92(a)] in THF (5 mL) was added NBS (0.33 g, 2.5 mmol). The reaction mixture was heated to 70° C. under nitrogen. After 2 h, the reaction mixture was concentrated under vacuum and purified on silica (EtOAc/hexanes, 10-30%) to afford the title compound (0.47 g, 78%). LC-MS (ES) m/z=316 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08273782B2 |
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| Source dataset | uspto-grants-2012_09 |
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| ORD ID | ord-b30216cc01204715a56c37b5f2642349 |
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| Source note | uspto-grants-2012_09 |
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