2-Methylpropanethioamide → HCID 57989663, compound

HRID 239245Notes

Reaction equation

HRID 239245 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([CH2:8][C:9]([C:11]2[CH:12]=[C:13]([NH:17][C:18](=[O:23])[O:19][CH2:20][CH:21]=[CH2:22])[CH:14]=[CH:15][CH:16]=2)=O)[CH:5]=[CH:4][N:3]=1.[CH3:24][CH:25]([CH3:29])[C:26](=[S:28])[NH2:27]>>[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[S:28][C:26]([CH:25]([CH3:29])[CH3:24])=[N:27][C:9]=2[C:11]2[CH:12]=[C:13]([NH:17][C:18](=[O:23])[O:19][CH2:20][CH:21]=[CH2:22])[CH:14]=[CH:15][CH:16]=2)[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 109095072-MethylpropanethioamideHCID 579899812-Propen-1-yl {3-[(2-chloro-4-pyrimidinyl)acetyl]phenyl}carbamate

Product 1

HCID 57989663HCID 57989663, compoundYield 45.9%

Procedure

Following a procedure analogous to the procedure described in Intermediate 6, using 2-propen-1-yl {3-[(2-chloro-4-pyrimidinyl)acetyl]phenyl}carbamate (10.0 g, 30.14 mmol), and 2-methylpropanethioamide (3.73 g, 36.17 mmol), prepared by a procedure analogous to Intermediate 1, 5.74 g of the title compound was obtained. MS (ESI): 415 [M+H]+.

Sources & evidence

ORD record
ord-ee94386607d847fcb09fadec20a41a18
Source dataset
uspto-grants-2014_02
Patent number
US08642759B2

Reaction notes

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