Methanol → Methyl 2-fluoro-3-nitrobenzoate

Temperature

70 °C

2-Fluoro-3-nitrobenzoic acid (75 g) was dissolved in 300 ml of methanol, and then 20 ml of concentrated H2SO4 was added. The mixture was stirred at 70° C. overnight and cooled to rt, the resulting solid was filtered and washed with water (3×200 ml), to the filtered was added water (400 ml), the resulting precipitate was filtered and washed with water (2×100 ml) to afford another batch of product. The solid were combined and dried under vacuum to afford the title compound was obtained as a light yellow solid (78 g, 96%).

1. temperaturecooled to rt
2. filtrationthe resulting solid was filtered
3. washwashed with water (3×200 ml), to the filtered
4. additionwas added water (400 ml)
5. filtrationthe resulting precipitate was filtered
6. washwashed with water (2×100 ml)
7. customto afford another batch of product
8. customdried under vacuum

ORD record

ord-e37aa0f5049040618f2d04b983fcc7c7

Source dataset

uspto-grants-2014_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08642759B2