2-Chloropyridine → 4-Piperidinemethanol,1-(4-pyridinyl)-

HRID 2392547Notes

Reaction equation

Cl[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[NH:8]1[CH2:13][CH2:12][CH:11]([CH2:14][OH:15])[CH2:10][CH2:9]1>>[N:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][OH:15])[CH2:10][CH2:9]1

Participants

Reactant 2

HCID 79772-Chloropyridine

HCID 4207714-Piperidinemethanol

Product 1

HCID 107741274-Piperidinemethanol,1-(4-pyridinyl)-Yield 80%

Procedure

The title compound (2.7 g, 80%) was prepared as a syrupy liquid from 2-chloropyridine (6.5 ml) and 4-piperidinyl methanol (2 g) by an analogous procedure to that described in preparation 1.

Workup

customthat described in preparation 1

Sources & evidence

ORD record: ord-00f61c25094d470f9f729929fa3bce14
Source dataset: uspto-grants-1998_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05801173

Reaction notes

Loading…