Methane → HCID 86753053, compound

Participants

Reaction Steps

To a 63° C. solution of 4-(6-fluorobenzo[b]thien-3-yl)-1-[4-(isoindol-2-yl)butyl]-piperazine (1.09 g, 2.66 mmol) in ethanol (40 mL) was added maleic acid (0.633 g, 5.45 mmol) and the resulting solution concentrated in vacuo to a dark foam. Trituration of the foam with ethanol/ethyl acetate gave a grey powder. The salt was treated with decolorizing charcoal in ethanol and recrystallized from ethanol to afford 1.08 g (63%) of the title compound as a grey powder, m.p. 153°-155° C.

Provenance & Evidence