Dimethylformamide → 4'-(Trifluoromethyl)-[1,1'-biphenyl]-2-carbonyl chloride

Participants

Reaction Steps

To a mixture of 4'-(trifluoromethyl)-[1,1'-biphenyl]-2-carboxylic acid (2.60 g, 9.77 mmol), catalytic DMF, and anhydrous dichloromethane (30 mL) at room temperature under nitrogen was added oxalyl chloride (1.38 g, 10.9 mmol) dropwise over 15 minutes and the reaction stirred at room temperature. After 18 hours, the yellow reaction solution was concentrated in vacuo to give 2.51 g of 4'-(trifluoromethyl)-[1,1'-biphenyl]-2-carbonyl chloride as a cloudy yellow liquid which was used without further purification.

Provenance & Evidence