4-Hydroxybenzaldehyde → HCID 18979539, compound

Participants

Reaction Steps

3.9 g of N,N'-dicyclohexylcarbodiimide were added at 0° C. within 15 minutes while stirring to a solution of 1.9 g of 4-hydroxybenzaldehyde, 5.0 g of 4-[8-acryloyloxyoctyloxy]benzoic acid and 0.1 g of 4-(dimethylamino)pyridine in 100 ml of dichloromethane. The reaction mixture was stirred at room temperature overnight, filtered and the filtrate was concentrated. Chromatographic purification of the residue on silica gel with cyclohexane/ethyl acetate (vol. 8:2) and two-fold recrystallization from ethyl acetate of the fractions which were pure according to thin-layer chromatography gave 5.5 g of 4-(4-[8-acryloyloxyoctyloxy]phenylcarbonyloxy)benzaldehyde; m.p. 73° C.

Provenance & Evidence