Acrylic Acid → HCID 18979511, compound

Participants

Reaction Steps

4.2 g of N,N'-dicyclohexylcarbodiimide were added within 5 minutes while stirring to a solution of 5.5 g of 4-(5-[8-hydroxyoctyloxy]pyrimidin-2-yl)benzaldehyde, 1.2 g of acrylic acid and 0.2 g of 4-(dimethylamino)pyridine in 25 ml of dichloromethane. The reaction mixture was stirred overnight, filtered and the filtrate was concentrated. Chromatography of the residue on silica gel with hexane/ethyl acetate (vol. 8:2) and recrystallization from ethyl alcohol of the fractions which were pure according to thin-layer chromatography gave 4.8 g of 4-(5-[8-acryloyloxyoctyloxy]pyrimidin-2-yl)benzaldehyde.

Provenance & Evidence