Acrylic Acid → HCID 178460483, compound

Participants

Reaction Steps

4.2 g of N,N'-dicyclohexylcarbodiimide were added within 5 minutes while stirring to a solution of 5.2 g of trans-4-(trans-4-[3-hydroxypropyl]cyclohexyl)cyclohexanecarboxylic acid, 1.2 g of acrylic acid and 0.2 g 4-(dimethylamino)pyridine in 25 ml of dichloromethane. The reaction mixture was stirred overnight, filtered and then concentrated. Chromatography of the residue on silica gel with hexane/ethyl acetate (vol. 8:2) and recrystallization from ethyl alcohol of the fractions which were pure according to thin-layer chromatography gave 4.2 g of trans-4-(trans-4-[3-acryloyloxypropyl]cyclohexyl)cyclohexanecarboxylic acid.

Provenance & Evidence