Acrylic Acid → HCID 178460466, compound

Participants

Reaction Steps

3.38 g of dicyclohexylcarbodiimide in 5 ml of dichloromethane was added dropwise while stirring at 0°-5° C. within 5 minutes to a solution of 6.2 g of 6-[4'-[trans-4-(2-[1,3]dioxolan-2-yl ethyl)cyclohexyl]-biphenyl-4-yloxy]-hexan-1-ol, 1.48 g of acrylic acid and 1.67 g of 4-dimethylamino-pyridine in 50 ml of dichloromethane. The reaction mixture was stirred overnight, filtered and then concentrated. Chromatography of the residue on silica gel with cyclohexane/ethyl acetate (vol. 8:2) gave 5.14 g of 6-[4'-[trans-4-(2-[1,3]dioxolan-2-yl-ethyl)-cyclohexyl]-biphenyl-4-yloxy]-hexyl acrylate.

Provenance & Evidence