HCID 9862516, compound → HCID 18980257, compound

HRID 2392606Notes

Reaction equation

HRID 2392606 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[NH:7][CH2:8][CH2:9][CH2:10][NH:11][CH2:12][CH2:13][O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[OH:21].[CH3:22][O:23]C1C(OC)=CC=CC=1OCCNCCCNC1NCCCN=1.[CH3:46]OC1C=CC=CC=1OCCNCCCNC1NCCCN=1.C(OC1C=CC=CC=1OCCNCCCNC1NCCCN=1)C.COC1C=CC=CC=1OCCCNCCCNC1NCCCN=1.O1C2C=CC=C(OCCNCCCNC3N=CC=CN=3)C=2OCC1.O1C2C=CC=C(OCCNCCCNC3NCCCN=3)C=2OCC1.O1C2C=CC=C(OCCNCCCCNC3NCCCN=3)C=2OCC1.C1(OCCNCCCNC2NCCCN=2)C2C(=CC=CC=2)C=CC=1>>[CH3:46][O:21][C:16]1[C:17]([O:23][CH3:22])=[CH:18][CH:19]=[CH:20][C:15]=1[O:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9][CH2:8][NH:7][C:2]1[N:3]=[CH:4][CH:5]=[CH:6][N:1]=1

Participants

10

Reactant 9

HCID 9862516HCID 9862516, compoundHCID 18980256HCID 18980256, compoundHCID 18980259HCID 18980259, compoundHCID 18980265HCID 18980265, compoundHCID 18980267HCID 18980267, compoundHCID 18980273HCID 18980273, compoundHCID 18980278HCID 18980278, compoundHCID 18980279HCID 18980279, compoundHCID 18980285HCID 18980285, compound

Product 1

HCID 18980257HCID 18980257, compound

Procedure

2-[2-[[3-(2-pyrimidinylamino)propyl]amino]ethoxy]phenol; N-[2-(2,3-dimethoxy- phenoxy)ethyl]-N'-(1,4,5,6-tetrahydro-2-pyrimidinyl)-1,3-propanediamine; N-[2-(2-methoxyphenoxy)ethyl]-N'-(1,4,5,6-tetrahydro-2-pyrimidinyl)-1,3-propane diamine; N-[2-(2-ethoxyphenoxy)ethyl]-N'-(1,4,5,6-tetrahydro-2-pyrimidinyl)- 1,3-propanediamine; N-[3-(2-methoxyphenoxy)propyl]-N'-( 1,4,5,6-tetrahydro-2- pyrimidinyl)-1,3-propanediamine; N-[2-[(2,3-dihydro-1,4-benzodioxin-5-yl)oxy]- ethyl]-N'-2-pyrimidinyl-1,3-propanediamine; N-[2-[(2,3-dihydro-1,4-benzodioxin-5-yl)- oxy]ethyl]-N'-(1,4,5,6-tetrahydro-2-pyrimidinyl)-1,3-propanediamine; N-[2-[(2,3-dihydro-1,4-benzodioxin-5-yl)oxy]ethyl]-N'-(1,4,5,6-tetrahydro-2- pyrimidinyl)-1,4-butanediamine; N-[2-(1-naphthalenyloxy)ethyl]- N'-(1,4,5,6-tetrahydro-2-pyrimidinyl)-1,3-propanediamine, the pharmaceutically acceptable acid addition salt thereof or the stereochemically isomeric forms thereof.

Sources & evidence

ORD record
ord-f5da7e8612b94e18941676f6aa3622c8
Source dataset
uspto-grants-1998_09
Patent number
US05801179

Reaction notes

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