反应详情

1-bromo-3-(2-methyl-allyloxy)-benzene, prepared by the alkylation of 1-bromo-3-hydroxy-benzene with 3-chloro-2-methyl-1-propene, was reacted with 4-benzyloxy-2-dimethylaminomethyl-cyclohexanone corresponding to the conditions described in Example 1. The base obtained was purified with 9:1 ether/methanol via a silica gel column, taken up in ether and treated with trimethylchlorosilane/water. Compound (4) was obtained.

1. customThe base obtained
2. customwas purified with 9:1 ether/methanol via a silica gel column
3. additiontreated with trimethylchlorosilane/water