Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Dimethylamine, hydrochloride | HCID 10473 | — |
| Reactant | HCID 15816724 | HCID 15816724 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 18980502 | HCID 18980502 | — |
Reaction Steps
11.8 g (50 mmole) of compound (8), 0.84 g (28 mmole) paraformaldehyde and 2.26 g (28 mmole) dimethylamine hydrochloride were dissolved in 20 ml acetic acid and stirred for 15 minutes in a bath at 105° C. After evaporating off the solvent, the mixture was adjusted to an alkaline pH with aqueous sodium hydroxide solution and the Mannich base was extracted with dichloromethane. The solution was dried and the solvent was distilled off. 12.1 g (80% theoretical) of compound (9) were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05801201 |
|---|
| Source dataset | uspto-grants-1998_09 |
|---|
| ORD ID | ord-a210672788a141168a5a724c9ac9af60 |
|---|
| Source note | uspto-grants-1998_09 |
|---|
