3-Bromoanisole → (1RS,2RS,4SR)-2-dimethylaminomethyl-4-isobutoxy-1-(3-methoxy-phenyl)-cyclohexanol hydrochloride

Participants

Reaction Steps

The base of compound (22) was reacted with 1-bromo-3-methoxy-benzene corresponding to the conditions described in Example 1. The base obtained was purified with 1:1 ethyl acetate/methanol via a silica gel column, and was taken up in ether. After adding trimethylchlorosilane/water, compound (20) was obtained in a yield of 38% theoretical.

Provenance & Evidence