反应详情

Compound (22) was reacted with 1-bromo-3-methylsulphanyl-benzene corresponding to the conditions described in Example 1. In departure from the conditions described in Example 1, ether was used as the solvent and 1,2-dibromoethane was added to the batch in order to increase the yield. The crude product obtained was purified with diisopropyl ether via a silica gel column, and was taken up in tetrahydrofuran/ether. The crystals obtained after adding trimethylchlorosilane/water were recrystallised from ethyl acetate. Compound (23) was obtained in a yield of 32% theoretical.

1. additionwas added to the batch in order
2. temperatureto increase the yield
3. customThe crude product obtained
4. customwas purified with diisopropyl ether via a silica gel column
5. customThe crystals obtained
6. customwere recrystallised from ethyl acetate