3-Bromoanisole → HCID 18980429, compound

HRID 2392752Notes

Reaction equation

HRID 2392752 reaction equation
[ClH:1].[CH2:2]([CH:9]1[CH2:14][CH2:13][C:12](=[O:15])[CH:11]([CH2:16][N:17]([CH3:19])[CH3:18])[CH2:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Br[C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([O:27][CH3:28])[CH:22]=1>>[ClH:1].[CH2:2]([CH:9]1[CH2:14][CH2:13][C:12]([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([O:27][CH3:28])[CH:22]=2)([OH:15])[CH:11]([CH2:16][N:17]([CH3:18])[CH3:19])[CH2:10]1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 169713-BromoanisoleHCID 18980436HCID 18980436, compound

Product 1

HCID 18980429HCID 18980429, compoundYield 55%

Procedure

The base of compound (36) was reacted with 1-bromo-3-methoxy-benzene corresponding to the conditions described in Example 1. The base obtained was purified with 7:1 ether/methanol via a silica gel column and was taken up in ether. After adding trimethylchlorosilane/water, compound (35) was obtained in a yield of 55% theoretical.

Workup

  1. customThe base obtained
  2. customwas purified with 7:1 ether/methanol via a silica gel column
  3. additionAfter adding trimethylchlorosilane/water

Sources & evidence

ORD record
ord-c687928ac5d14ac2a9d58658d00e106a
Source dataset
uspto-grants-1998_09
Patent number
US05801201

Reaction notes

Loading…