3-Bromoanisole → HCID 18980478, compound

HRID 2392755Notes

Reaction equation

HRID 2392755 reaction equation
[ClH:1].[CH3:2][N:3]([CH2:5][CH:6]1[CH2:11][CH:10]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([CH3:19])=[CH:15][CH:14]=2)[CH2:9][CH2:8][C:7]1=[O:20])[CH3:4].Br[C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[CH:23]=1>>[ClH:1].[CH3:2][N:3]([CH2:5][CH:6]1[CH2:11][CH:10]([CH2:12][C:13]2[CH:14]=[CH:15][C:16]([CH3:19])=[CH:17][CH:18]=2)[CH2:9][CH2:8][C:7]1([C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([O:28][CH3:29])[CH:23]=1)[OH:20])[CH3:4]

Participants

3

Reactant 2

HCID 169713-BromoanisoleHCID 18980424HCID 18980424, compound

Product 1

HCID 18980478HCID 18980478, compoundYield 39%

Procedure

The base of compound (42) was reacted with 1-bromo-3-methoxy-benzene corresponding to the conditions described in Example 1. The base obtained was purified with 7:1 ether/methanol via a silica gel column and was taken up in ether. After adding trimethylchlorosilane/water, compound (44) was obtained in a yield of 39% theoretical.

Workup

  1. customThe base obtained
  2. customwas purified with 7:1 ether/methanol via a silica gel column
  3. additionAfter adding trimethylchlorosilane/water

Sources & evidence

ORD record
ord-9eec3eb5862a4555ae12ed88b2588ff5
Source dataset
uspto-grants-1998_09
Patent number
US05801201

Reaction notes

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