HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (1RS,2RS,4SR)-3-(2-dimethylaminomethyl-1-hydroxy-4-phenethyl-cyclohexyl)-phenol hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-(3-Benzyloxyphenyl)-2-dimethylaminomethyl-4-phenethyl-cyclohexanol | HCID 18980508 | — |
| Reactant | Chlorotrimethylsilane water | HCID 86753056 | — |
| Product | (1RS,2RS,4SR)-3-(2-dimethylaminomethyl-1-hydroxy-4-phenethyl-cyclohexyl)-phenol hydrochloride | HCID 18980488 | 63% |
Reaction Steps
Compound (50) was hydrogenated corresponding to the conditions described in Example 23, step 2. The base obtained was converted into the hydrochloride with trimethylchlorosilane/water. Compound (49) was obtained in a yield of 63% theoretical.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05801201 |
| Source dataset | uspto-grants-1998_09 |
| ORD ID | ord-972526bbaa5a4c5ea939fe2b93a50068 |
| Source note | uspto-grants-1998_09 |