HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromophenetole → (1RS,2RS,4SR)-4-(cyclopentylethyl)-2-dimethylaminomethyl-1-(3-ethoxyphenyl)-cyclohexanol hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromophenetole | HCID 75867 | — |
| Reactant | 4-(2-Cyclopentyl-ethyl)-2-dimethylaminomethyl-cyclohexanone hydrochloride | HCID 18980413 | — |
| Product | (1RS,2RS,4SR)-4-(cyclopentylethyl)-2-dimethylaminomethyl-1-(3-ethoxyphenyl)-cyclohexanol hydrochloride | HCID 67642001 | 52% |
Reaction Steps
The base of compound (56) was reacted with 1-bromo-3-ethoxy-benzene corresponding to the conditions described in Example 1. The base obtained was purified with diisopropyl ether via a silica gel column and was taken up in 2-butanone/ether. After adding trimethylchlorosilane/water, compound (58) was obtained in a yield of 52% theoretical.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05801201 |
| Source dataset | uspto-grants-1998_09 |
| ORD ID | ord-5703f94db2e5419c85bcb4823a696efd |
| Source note | uspto-grants-1998_09 |