Diethyl Ether → HCID 18980435, compound

Participants

Reaction Steps

130 g (0.83 mole) 1,4-dioxa-spiro[4.5]-decan-8-one and 79.5 g (0.83 mole) dimethylammonium methylene chloride were stirred in 500 ml acetonitrile at room temperature. After adding 1 ml acetyl chloride, the mixture was stirred for 3 hours at room temperature, whereupon a clear, colourless solution was formed. 1 litre ether was then added drop-wise to the reaction mixture. 203 g (98% theoretical) 7-dimethylaminomethyl-1,4-dioxa-spiro[4.5]decan-8-one hydrochloride (64) were obtained in crystalline form.

Provenance & Evidence