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Sodium Iodide → 3-[4-[1-(3-Chlorophenyl)-4-piperazinyl]butyl]-2-Methyl-4-thiazolidinone hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-(3-Chlorophenyl)piperazine monohydrochloride | HCID 25681 | — |
| 反応物 | 3-(4-Bromobutyl)-2-methyl-4-thiazolidinone | HCID 10490993 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 3-[4-[1-(3-Chlorophenyl)-4-piperazinyl]butyl]-2-Methyl-4-thiazolidinone hydrochloride | HCID 14856141 | — |
反応手順
To a solution of 2-methyl-3-(4-bromobutyl)-4-thiazolidinone (4.0 g) and 1-(3-chlorophenyl)piperazine hydrochloride (3.69 g) in 100 ml of dry CH3CN were added K2CO3 (8.8 g) and NaI (200 mg). The mixture was heated to reflux with stirring under N2.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05801186 |
| 出典データセット | uspto-grants-1998_09 |
| ORD ID | ord-3344c7f16f694860abbbf2f79dd126b3 |
| 出典メモ | uspto-grants-1998_09 |