Hydrochloric Acid → HCID 178527047, compound

Participants

Reaction Conditions

Reaction Steps

0.50 g (12.6 mmol) of NaOH in 7 ml of water are added dropwise at 23° C. to a solution of 2.50 g (6.3 mmol) of isobutyl (3-diphenylphosphinophenyl)methylphosphinate in 7 ml of THF. After refluxing for 6 hours, 1.04 ml (12.6 mmol) of concentrated hydrochloric acid are added dropwise at 23° C., the mixture is stirred for 10 min at 23° C. and evaporated to dryness under reduced pressure. The residue is substantially dissolved in boiling methanol, filtered hot and crystallized for 22 h at -20° C. 1.02 g of (3-diphenylphosphinophenyl)methylphosphinic acid (60% of theory) are obtained in the form of a colorless solid having an m.p. of 173° C.

Provenance & Evidence